The defragmenter tool refuses to defragment either of my 1TB SATA drives, with the analysis result stat "Defragmentation not recommended for this volume". Normally, I would assume that this meant that there was no/little fragmentation, but even Defraggler says that one of the partitions (that I use a download repository) has around 15% fragmentation. On my laptop, BitDefender will offer to defrag drives that show no fragmentation, and even drives that it has just defragmented.
BitDefender will allow either of my external USB HDDs to be defragmented on this PC.
This isn't a RAID array, or any unusual configuration. One drive is a single 1TB partition, the other is split into 4 partition (required Win7 System partition, 2 other primary partitions, and 1 logical). All are NTFS formatted, created by either Windows 7 installation or via Windows' disk management.
The HDDs are both Western Digital WD1002FAEX connected to the Intel Z68 chipset's SATA ports on my motherboard (Asus P8Z68-V Pro). The only non-default/required aspect that I can think of related to the HDDs is Intel's Rapid Storage Technology driver being installed (version 10.6.2.1001 supplied by Asus). In this non-RAID configuration, that is only an optimized driver for the controller.