For some time now I had the problem that I couldn't play embedded YouTube videos (e.g. on patreon and gog.com). The frame would just display "Error 153" briefly and then go black.
Only yesterday figured out that this is caused by the BitDefender browser extension, which blocks a required cookie from youtube-nocookie.com
Whitelisting that domain in the settings of the extension fixed the problem for me. IMHO BitDefender should whitelist the domain out of the box, because this severely disrupts legitimate use-cases and was not easy to diagnose - even for a Pro like me.