I too, have this problem. I am using the Internet Security 2012. The application that I found this problem is on a program called iw5sp.exe, (Call of Duty Modern Warfare 3) and generals.exe, shockwave.exe (Generals Shockwave Mod for Zero Hour).
I have tried to reinstall and format my computer and thought this problem is fixed though, but it seems not.
I also tried to reinstall the game and added them into either Exception List and Game Mode, but the error 'this application cannot run in the virtual machine' still appears, other games like #### Manager 12, Need for Speed Hot Pursuit seems fine.
Except that, I cannot recover the files deleted by Active Virus Control too (through AutoPilot Mode).
Any solution for this is appreciated!