Nox App Player is an Android emulator for PC and whem I'm using it, this file 'noxvmhandle.exe' points to the website 'http://noxagile.duapp.com/stup.php'that is detected as infected.
I ran it in VirusTotal.com and only BitDefender and AutoShun are reporting it as malicious which leads me to think it's a false positive.
