I use Bitdefender Internet Security 2016.
In two days Bitdefender has blocked two installs of perfectly safe software. It does so without any sort of popup or notification, and I had to search online to find out the antivirus was the culprit.
One was the game "The Book of Unwritten Tales 2" through the GOG galaxy client (GOG's shop and game library application), and the other blocked updating the AMD driver through the Catalyst Control Centre update feature.
I know I've had incidents before. If this continues to be a problem I will have to change to another security provider.