A copy and paste of the email I sent to BD support after a phone call...
I followed the directions from the link. None of the changes helped. No individual module whether off or on is affecting the behaviour. The only thing that restores the normal function is to re-boot the computer and this only works once.
I will describe the bug so it is in writing...
I am running two computers, one is a custom made PC from a local shop and one is an ASUS notebook. Both are running Windows 10 21H2 19044.1526 with Bitdefender Internet Security, Build 26.0.12.52 as the only security software. The bug has only appeared after the automatic update from BD build 45 to 52 in the last 24 hours. The behaviour did not occur prior to this update. Both computers are affected.
The bug is that a USB device will only show once after a system start or reboot. After showing once and then removed, no USB storage device (the one removed or any other) will show in My Computer and the taskbar symbol with "Safely Remove Hardware and Eject Media" message on clicking is missing. Normal behaviour is restored after a re-boot but it only works once. The Windows alert sounds every time a USB storage device is plugged in or unplugged.
Operation of USB connected game controllers is unaffected and the USB ports remain powered - I can feel the WD 2TB spinners starting up when plugged in even when they don't show.
As part of my trouble-shooting I completely uninstalled Bitdefender Internet Security. Normal USB function is restored. When re-installed, the bug returned. I did this twice to be sure.
Your latest build definitely has a bug.